Endocrine Abstracts

Aim: To assess factors affecting HV during triptorelin suppression treatment for CPP.Materials and methods: Forty-six girls with CPP, with mean age at diagnosis 8.4 yrs who presented with signs and symptoms of puberty before the age of 8 years and were treated with triptorelin for at least 2 years, were studied. All girls were categorized into three groups according to the difference between bone age (BA) and chronological age (ΔBA-CA): group I with...

Introduction: Recent years PEIT has been introduced as an alternative to parathyroidectomy. We evaluated the results of PEIT in patients with primary (pHPT) or secondary hyperparathyroidism (sHPT).Patients and methods: 18 patients (6M/12F) with pHPT and 20 patients (7M/13F) with sHPT underwent PEIT between 2001 and 2005 and had a mean follow up of 24.3±9 and 27±10 months respectively. The PTGs were identified and blood supply to the gland was e...

Introduction: The results of this epidemiological study demonstrate the burden of 25-hydroxyvitamin D deficiency in two sunny Mediterranean countries Greece and Cyprus- and some of the related risk factors. These two populations were examined together due to their common phylogenetic origin. Up until now there are no available data for the mean Vitamin D levels of the Cypriot adult population. An early identification of vitamin D deficiency is now considered as the cornerstone...

Introduction: Ganglioneuromas (GNs) are rare, benign tumors, arising from neural crest cells. Their incidence amongst adrenal masses is 0.3%-6%. The majority are incidentalomas and hormonally inactive but a subset may cause compressive effects. Presentation in the context of genetic syndromes (NF1/NF2, RET, MAX, Von Hippel Lindau disease) has been reported. We present two cases of adrenal GNs: Case 1. A 31-year-old female patient who presented with a history o...

Introduction: National guidance from the Association of Children’s Diabetes Clinicians (ACDC) recommends starting children with newly diagnosed type 1 diabetes mellitus on a total daily insulin dose of 0.5–0.75 iU per kilo per day (kg/d). This equates to a basal insulin dose of between 0.25–0.375 iU/kg per day. Local practice suggested many patients required a significantly smaller starting dose of basal insulin.Ai...

Introduction: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formerly known as type II enteropathy-associated T-cell lymphoma, is a rare and aggressive subtype of lymphoma of the gastrointestinal track typically noted in Asian or Hispanic populations. Adrenal involvement as part of MEITL is extremely rare. Herein we present a patient of Greek origin with MEITL and bilateral adrenal metastases.Case Presentation: A 74-year-old man presente...

Background: Data on the effects of different dietary patterns on free 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations are scarce. Our objective was to prospectively assess changes over time in these parameters and possible correlations with diet composition among overweight adults who followed a pescatarian Orthodox intermittent fasting (OF) regimen and controls who followed a low-fat 12:12 diet for 7 weeks.Methods: Tota...

Objective: Bleeding is one of the most dangerous complications following thyroid and parathyroid surgery. For this reason prophylactic perioperative thromboprophylaxis is not routinely use. The aim of this study is to investigate the incidence of clinical and subclinical deep vein thrombosis (DVT) and to validate the Caprini score as a predictive factor of high risk patients after these operations.Material and method: This is a prospective study involvin...

Tocilizumab is an interleukin-6 receptor antagonist used in the treatment of rheumatoid arthritis (RA). It is known to induce remission and inhibit radiographic progression in RA. Tocilizumab may be administered either intravenously or subcutaneously. Its effect on lipid levels and the cardiovascular risk has not been fully investigated. The aim was to study the effect of tocilizumab administered either iv or sc on disease activity, lipid levels and cardiovascular risk in RA p...

Familial glucocorticoid deficiency (FGD;OMIM 202200) results from the inability of the adrenal cortex to produce cortisol in response to ACTH stimulation. Half of all cases are caused by mutations in MC2R, MRAP or STAR. SNP array genotyping of FGD patients of unknown aetiology mapped a disease locus to chromosome 5p13-q12. Targeted exome sequencing of 5p13-q12 in one patient identified a homozygous mutation, p.Ala533Val, in nicotinamide nucleotide transhyd...